Another intriguing difference lies in the effect on Sex Hormone Binding Globule (SHBG). SHBG is a naturally produced glycoprotein that binds to testosterone, making it unavailable for purposes such as building muscle. StanoGen is able to cause a lowering of SHBG and therefore free up more testosterone within the body. However, due to oral StanoGen having to first pass through the liver (where SHBG is produced), whereas injectable StanoGen doesn’t have to complete this first pass, oral StanoGen has a greater effect on lowering SHBG levels , and freeing up more testosterone.
Winstrol is hepatotoxic, and because of this, it should be used at the lowest effective dose for the shortest possible cycle. What’s more, you should consider using a supplement designed to provide some additional protection. Milk thistle is a highly recommended option; studies suggest it can provide an effective layer of protection when it is used for the entire length of your cycle. There are some other supplements on the market, such as Liver Care, which are blends of natural ingredients that have been shown to work together to prevent liver toxicity.
Side effects that are a little more exclusive to Winstrol Depot have much to do with the uncomfortable and highly irritating injections (resulting almost exclusively from the suspension format). It is not uncommon to have very sore injection sites in the hours and days following administration, and to have a significant loss of range of motion of that muscle due to the pain. Often times, bodybuilders will even have to shift and schedule workouts around their Winstrol Depot injections, as the muscles injected might be too sore and tender to train soon afterwards. Winstrol itself carries with it comes significant side effects as well, most particularly the significant negative impacts on cholesterol levels in the body. Winstrol is notorious for reducing HDL (good cholesterol) levels and increasing LDL (bad cholesterol) levels in the body, which can contribute to increased risk for cardiovascular disease if left negatively altered for extended periods of time. Proper supplementation with cardiovascular supportive nutrients and compounds are highly advised. Being that Winstrol Depot is also C17AA modified, it does exhibit potential liver toxicity, although less so than its oral counterpart. Regardless, it is highly advised to include proven effective liver support compounds (such as TUDCA and/or NAC) during a cycle of Winstrol Depot.