yes I think you are all very right. I tend to wake up in the morning, and take all my medications at once,, regardless of spreading it out or anything. So quite often I end up feeling sick, with a headache, and quite dreadful. I take 125 of Levo, which maybe I could space out a bit, and I also take slow release Tramadol, and topamax, and fentanyl patches..(which are of course, spread out over 72 hours) So I am, I guess just about at the top of what I could reasonably take. Well I still have dreadful pain. I guess I just have to learn how to put up with it!!