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Diarrhea is more common and sometimes more severe with flutamide than with other NSAAs. [51] In a comparative trial of combined androgen blockade for prostate cancer, the rate of diarrhea was 26% for flutamide and 12% for bicalutamide. [51] Moreover, 6% of flutamide-treated patients discontinued the drug due to diarrhea, whereas only % of bicalutamide-treated patients did so. [51] In the case of antiandrogen monotherapy for prostate cancer, the rates of diarrhea are 5–20% for flutamide, 2–5% for bicalutamide, and 2–4% for nilutamide . [51] In contrast to diarrhea, the rates of nausea and vomiting are similar among the three drugs. [51]

Some bodybuilders and athletes use trenbolone esters for their muscle-building and otherwise performance-enhancing effects. [5] Such use is illegal in the United States and many other countries. The DEA classifies trenbolone and its esters as Schedule III controlled substances under the Controlled Substances Act . [19] Trenbolone is classified as a Schedule 4 drug in Canada [20] and a class C drug with no penalty for personal use or possession in the United Kingdom . [21] Use or possession of steroids without a prescription is a crime in Australia . [22]

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