Propionates 280-283

If you suspect that your child has an allergy or food intolerance you can get a referral from your doctor to see your nearest allergy testing unit. Testing for allergies includes a skin prick test (SPT) or the radioallergosorbent test (RAST) and intolerances are detected using an elimination diet.

If your child has an allergy, especially a nut allergy, it is important that his or her school has an anaphylaxis policy, this is where no nut products are sold in the school canteen, and no children in the school are to bring any nut products to school. A nut allergy can have fatal consequences; sensitivity can be so severe that a child with a nut allergy may have a reaction after being breathed on by someone who has just eaten nuts.

It is important that teachers at the school are trained in how to use an epipen® (a shot of adrenalin used in the case of anaphylaxis). This training is available for teachers and all teachers can be trained in one session. Visit for more details.


My daughter, who is now 7 years old and who began the failsafe approach at age 3, reacts in the following ways whenever she has 282 in bread. She becomes defiant, hyperactive, impossible to reason with, plain silly, very loud, noisy, annoying to others, demanding, pushy, and if something doesn't go her out...fully blown tantrum including slamming doors, storming out the house, screaming, yelling, crying that goes on for a long time. Can't and won't follow simple instructions, becomes distracted easily, goes off track and off task, becomes destructive She also finds settling at night really difficult ... can't seem to switch off. The next day she realizes that it was the 282 that made her feel that way ... and she genuinely can't refrain from behaving in this way. We are pleased though that as she grows her reactions seem to be becoming slightly less severe. I think this has to do with more careful diet, increased body weight, and increased maturity on her part.

The EFSA ANS Panel provides a scientific opinion re-evaluating the safety of propionic acid (E 280), sodium propionate (E 281), calcium propionate (E 282) and potassium propionate (E 283) which are authorised as food additives in the EU and have been previously evaluated by the SCF and JECFA. JECFA allocated an ADI “not limited”. The SCF concluded that potassium propionate could be added to the list of preservatives and established an ADI ”not specified”. Propionates are naturally occurring substances in the normal diet. The Panel considered that forestomach hyperplasia reported in long-term studies in rodents is not a relevant endpoint for humans because humans lack this organ. Based on the reported presence of reversible diffuse epithelial hyperplasia in the oesophagus the LOAEL for a 90-day study in dogs was considered by the Panel to be 1 % propionic acid in the diet and the NOAEL to be  % propionic acid in the diet. The Panel considered that there is no concern with respect to genotoxicity and carcinogenicity. The Panel concluded that the present database did not allow allocation of an ADI for propionic acid - propionates. The overall mean and 95 th percentile exposures to propionic acid - propionates resulting from their use as food additives (major contributor to exposure) ranged from - and - mg/kg bw/day, respectively. The Panel noted that the concentration provoking site of contact effect in the 90-day study in dogs (1 % propionic acid in the diet) is a factor of three higher than the concentration of propionic acid - propionates in food at the highest permitted level and concluded that for food as consumed, there would not be a safety concern from the maximum concentrations of propionic acid and its salts at their currently authorised uses and use levels as food additives.

Propionates 280-283

propionates 280-283